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Comprehensive Review on Alzheimer Disease Discussion Paper

Comprehensive Review on Alzheimer Disease Discussion Paper

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Alzheimer’s Disease and Treatment

The prevalence rate of elderly patients with dementia may result in a health crisis in the future. Alzheimer’s disease is a condition whereby the brain causes problems in memories and behaviors and it continues to deteriorate as it gradually progresses. The main risk factor associated with Alzheimer’s condition is age. However, other factors such as head injuries, genetics, and down-syndrome may cause Alzheimer’s (Breijyeh & Karaman, 2020). This paper aims to discuss a case study of an elderly with Alzheimer’s disease and its treatment options.  Comprehensive Review on Alzheimer Disease Discussion Paper

Summary of the Case Study

The case study involves Mr. Akkad, a 76-year-old Iranian male who was brought by his eldest son to the facility. The son reported that Mr. Akkad’s behavior had changed over the past two years, which included his memory loss, challenges to identify appropriate words when conversing, apathy, and personality changes. From the son’s report, it was identified that his behavior change was not associated with any organic disease processes. A personal examination was conducted on the patient confabulation was identified and a deficit in orientation, attention, and recall. The results showed moderate dementia, which is a neurocognitive disorder caused by Alzheimer’s disease.

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The Decisions and Supporting Evidence-based Literature

The first decision made will be administering a dosage of Donepezil 5mg at bedtime. Research on the effectiveness of donepezil in the treatment of Alzheimer’s disease has been ongoing for decades. The drug is an acetylcholinesterase inhibitor, which works by increasing acetylcholine levels in the brain which is usually caused by the reduced functioning of the cholinergic neurons (Li et al., 2018). A research trial on the effects of donepezil on Alzheimer’s patients showed that the medication is effective in the management of behavior, cognition, and functioning. Therefore, since the patient had a behavioral change in his personality, memory, and utterances, the decision would help manage and improve his condition. Comprehensive Review on Alzheimer Disease Discussion Paper

The second approach would involve cognitive behavioral treatment; which research has identified to be an effective method early stages of Alzheimer’s condition. Evidence has shown that psychosocial approaches are effective in the management of behaviors associated with dementia (Spector et al., 2015). Thus cognitive behavioral therapy would have supported the change in behavior of the patient. The last decision involves using disease-modified therapeutics, whereby the approach works by altering the progression of the condition through different mechanisms (Breijyeh & Karaman, 2020). Through immunotherapies and drug administration, a trial has shown that anti-amyloid agents and Aβ monoclonal are effective disease-modifying agents. Therefore, using this approach would prevent further advancement of the condition of the patient.

Expectations on the Decisions

The first decision involving the use of donepezil 5mg during bedtime is expected to bring about symptomatic treatment. In this case, the drug will increase cholinergic levels, which helps increase cognitive and neural cell functioning (Breijyeh & Karaman, 2020). The second approach is also expected to manage behavioral symptoms including memory loss and conversing appropriately. The third approach aims to alter the progression of the condition by altering different pathophysiological mechanisms that may cause the progression of the condition.

The three approaches chosen for the patients would focus on managing behavioral symptoms, maintaining mental functioning, and reducing the progression of the disease. All the decisions supported the expectations. The results of the decision in the exercise aimed to manage the symptoms which were not different from one of three decisions that involved administering donepezil 5mg during bedtime. Comprehensive Review on Alzheimer Disease Discussion Paper

 

 

 

References

Breijyeh, Z., & Karaman, R. (2020). Comprehensive Review on Alzheimer’s Disease: Causes and Treatment. Molecules25(24), 5789. https://doi.org/10.3390/molecules25245789

Li, Q., He, S., Chen, Y., Feng, F., Qu, W., & Sun, H. (2018). Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer’s disease. European Journal Of Medicinal Chemistry158, 463-477. https://doi.org/10.1016/j.ejmech.2018.09.031

Spector, A., Charlesworth, G., King, M., Lattimer, M., Sadek, S., & Marston, L. et al. (2015). Cognitive–behavioural therapy for anxiety in dementia: pilot randomised controlled trial. British Journal Of Psychiatry206(6), 509-516. https://doi.org/10.1192/bjp.bp.113.140087

Review the interactive media piece assigned by your Instructor.
Reflect on the patientâ€s symptoms and aspects of the disorder presented in the interactive media piece.
Consider how you might assess and treat patients presenting with the symptoms of the patient case study you were assigned.
You will be asked to make three decisions concerning the diagnosis and treatment for this patient. Reflect on potential co-morbid physical as well as patient factors that might impact the patientâ€s diagnosis and treatment.
By Day 7 of Week 8
Write 2-page summary paper that addresses the following: Comprehensive Review on Alzheimer Disease Discussion Paper

Briefly summarize the patient case study you were assigned, including each of the three decisions you took for the patient presented.
Based on the decisions you recommended for the patient case study, explain whether you believe the decisions provided were supported by the evidence-based literature. Be specific and provide examples. Be sure to support your response with evidence and references from outside resources.
What were you hoping to achieve with the decisions you recommended for the patient case study you were assigned? Support your response with evidence and references from outside resources.
Explain any difference between what you expected to achieve with each of the decisions and the results of the decision in the exercise. Describe whether they were different. Be specific and provide examples.

For your Assignment, you are assigned the Alzheimerâ€s decision tree interactive media pieces provided in the Resources. As you examine the patient case studies in this moduleâ€s Resources, consider how you might assess and treat patients presenting symptoms of neurological and musculoskeletal disorders. Comprehensive Review on Alzheimer Disease Discussion Paper

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