Treating Bipolar Disorder In Pregnant Women Discussion

Treating Bipolar Disorder In Pregnant Women Discussion

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Response to Discussion


I greatly appreciate the work you did in your discussion on treating bipolar disorder in pregnant women. Going through it, I was able to learn about three options that can be safely used to manage bipolar disorder in pregnant women. This includes either using an FDA-approved drug (Lithium), off-label medication (Lamotrigine), or a nonpharmacological intervention (CBT and Interpersonal and Social Rhythm Therapy)Treating Bipolar Disorder In Pregnant Women Discussion. Throughout the discussion, my attention was caught by the use of lithium.


Among the most challenging clinical tasks is treating bipolar disorder in pregnant women. Every step of the way challenges patients and physicians, and no strategy is risk-free. Restarting efficacious medication throughout pregnancy exposes the patient and fetus to possible risks associated with bipolar relapses and dysfunction related to lingering mood symptoms (Sharma et al., 2020). For many, these events can be avoided by continuing effective medication during pregnancy; nonetheless, congenital abnormalities or other unfavorable neonatal outcomes have been linked to some of the most successful medications (such as valproate) (Sharma et al., 2020)Treating Bipolar Disorder In Pregnant Women Discussion. Thus, the choice of lithium as the safest medication was excellent.

Considerably, when taken as directed, lithium has been demonstrated to be the most effective preventive option for the treatment of bipolar disorder (and other psychiatric disorders such as schizoaffective disorder and recurrent major depression), even in the perinatal period. Its side effect profile is also more favorable than is commonly believed. Additionally, the FDA in the United States issued a warning regarding the use of antipsychotics during the peripartum period. The risk of carbamazepine syndrome and fetal valproate (as well as the drug’s proven neurodevelopmental teratogenicity) makes it inappropriate to use these medications during this stage of the female reproductive cycle (Fornaro et al., 2020)Treating Bipolar Disorder In Pregnant Women Discussion.

The majority of the information about drugs other than lithium is anecdotal or out-of-date, which further complicates the clinical decision. Although some guidelines, like the National Institute for Health and Care Excellence guidelines, specify that taking lithium is not advised, particularly in the first trimester of pregnancy, it is important to note that “evidence-based” guidelines may not align with “consensus-based” guidelines, which must consider the evidence regarding safety and efficacy (Fornaro wet al., 2020)Treating Bipolar Disorder In Pregnant Women Discussion.


Fornaro, M., Maritan, E., Ferranti, R., Zaninotto, L., Miola, A., Anastasia, A., … & Solmi, M. (2020). Lithium exposure during pregnancy and the postpartum period: a systematic review and meta-analysis of safety and efficacy outcomes. American Journal of Psychiatry177(1), 76-92.

Sharma, V., Sharma, P., & Sharma, S. (2020). Managing bipolar disorder during pregnancy and the postpartum period: a critical review of current practice. Expert review of neurotherapeutics20(4), 373-383. Treating Bipolar Disorder In Pregnant Women Discussion

Decide if you think leaders are made or born.
Conduct research to find credible sources that support your position.

Assignment Directions
Your original response should address the following:

Identify your position on whether leaders are made or born, and support that position with appropriate resources.
Provide examples and resources that support your position.

In your follow-up responses, you should do the following:

Choose an original peer response that opposes your position, and present arguments for the validity of your position.
Present your arguments using credible resources.
Go back to your original response and let us know if you have changed your position after reading your peers’ positions and supporting evidence. It is OK to change your position after reading peer responses that are convincing.

Post your original response.
Use sources that are within 5 years of publication
Post a minimum of 2 follow-up responses.
Check your syllabus for specific due dates.
See the rubric for graded content description.
In order to easily meet the minimum curiosity points, please use the Bloom’s verbs when posing your initial question. See Unit 1/Week 1 Packback Directions for Bloom’s information.

Packback Questions
Participation is a requirement for this course, and the Packback Questions platform will be used for online discussion about class topics. Packback Questions is an online community where you can be fearlessly curious and ask open-ended questions to build on top of what we are covering in class and relate topics to real-world applications.


Packback Requirements:
Your participation on Packback counts as a weighted percentage of your overall course grade. Each Packback Discussion is worth a total of 10 points.

There will be a Sunday 11:59PM deadline for submissions in the units that have a Packback assignments. In order to receive full credit, you should submit the following per each deadline period:

1 open-ended Question every week with a minimum Curiosity Score of >90, worth 5pts of each assignment grade
2 Responses every week with a minimum Curiosity Score of >90, worth 5pts of each assignment grade
Half credit will be provided for questions and responses that do not meet the minimum curiosity score based on quality of topic input.
You must head the question by first inserting the Unit # and Week # – if the instructor is unsure which unit and week of the discussion posting that discussion is at risk for not being graded. An example of the Packback discussion question is below:
Unit 1 Week 1: Which policies construct exemplary retention for healthcare personnel during a pandemic?

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