Discussion On Treating Major Depressive Disorder

Discussion On Treating Major Depressive Disorder

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I was privileged to go through your discussion on treating Major Depressive Disorder (depression) in older adults. I must say that I was impressed by your approach towards this discussion. I agree with your choice of medications, both FDA-approved and off-label, as well as the non-pharmacological intervention. It is impressive that you note that when treating older adults with depression using SSRIs (Selective Serotonin Reuptake Inhibitors), several considerations should be taken into account to ensure safe and effective treatment (Ghaffari et al., 2020)Discussion On Treating Major Depressive Disorder . To add on what you found out other considerations when treating this population include; medical history and comorbidities, renal and hepatic function, congestive function, and polypharmacy.


Therefore, it is crucial for healthcare providers to approach the treatment of depression in older adults with a comprehensive and individualized strategy, taking into account the specific challenges and considerations associated with this population. Additionally, collaboration between healthcare professionals, caregivers, and the patient is essential for optimal outcomes. It is essential to note that the effectiveness of non-pharmacological interventions can vary, and a combination of approaches may be most beneficial (Burke et al., 2019). Additionally, individual preferences, cultural considerations, and the severity of depression should be taken into account when tailoring a treatment plan for older adults with major depressive disorder. For instance, compared to your choice – Life Review Therapy, CBT (Cognitive Behavioral Therapy) is a widely researched and effective form of psychotherapy (Köhler‐Forsberg et al., 2019)Discussion On Treating Major Depressive Disorder . It helps individuals identify and change negative thought patterns and behaviors associated with depression. Additionally, consulting with a mental health professional is recommended to determine the most appropriate interventions for a specific individual.


Burke, A. D., Goldfarb, D., Bollam, P., & Khokher, S. (2019). Diagnosing and treating depression in patients with Alzheimer’s disease. Neurology and therapy8, 325-350.

Ghaffari Darab, M., Hedayati, A., Khorasani, E., Bayati, M., & Keshavarz, K. (2020). Selective serotonin reuptake inhibitors in major depression disorder treatment: an umbrella review on systematic reviews. International Journal of Psychiatry in Clinical Practice24(4), 357-370.

Köhler‐Forsberg, O., N. Lydholm, C., Hjorthøj, C., Nordentoft, M., Mors, O., & Benros, M. E. (2019). Efficacy of anti‐inflammatory treatment on major depressive disorder or depressive symptoms: meta‐analysis of clinical trials. Acta Psychiatrica Scandinavica139(5), 404-419.

Discussion On Treating Major Depressive Disorder

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