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The Tragedy of Vaccine Nationalism

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By Thomas J. Bollyky and Chad P. Bown September/October 2020

Trump administration officials have compared the global allocation of vaccines
against the coronavirus that causes COVID-19 to oxygen masks dropping inside a
depressurizing airplane. “You put on your own first, and then we want to help
others as quickly as possible,” Peter Marks, a senior official at the U.S. Food and
Drug Administration who oversaw the initial phases of vaccine development for the
U.S. government, said during a panel discussion in June. The major difference, of
course, is that airplane oxygen masks do not drop only in first class—which is the
equivalent of what will happen when vaccines eventually become available if
governments delay providing access to them to people in other countries.

By early July, there were 160 candidate vaccines against the new coronavirus in
development, with 21 in clinical trials. Although it will be months, at least, before
one or more of those candidates has been proved to be safe and effective and is
ready to be delivered, countries that manufacture vaccines (and wealthy ones that
do not) are already competing to lock in early access. And to judge from the way
governments have acted during the current pandemic and past outbreaks, it seems
highly likely that such behavior will persist. Absent an international, enforceable
commitment to distribute vaccines globally in an equitable and rational way,
leaders will instead prioritize taking care of their own populations over slowing the
spread of COVID-19 elsewhere or helping protect essential health-care workers and
highly vulnerable populations in other countries.

That sort of “vaccine nationalism,” or a “my country first” approach to allocation,
will have profound and far-reaching consequences. Without global coordination,
countries may bid against one another, driving up the price of vaccines and related
materials. Supplies of proven vaccines will be limited initially even in some rich
countries, but the greatest suffering will be in low- and middle-income countries.
Such places will be forced to watch as their wealthier counterparts deplete supplies
and will have to wait months (or longer) for their replenishment. In the interim,
health-care workers and billions of elderly and other high-risk inhabitants in poorer
countries will go unprotected, which will extend the pandemic, increase its death
toll, and imperil already fragile health-care systems and economies. In their quest
to obtain vaccines, countries without access to the initial stock will search for any
form of leverage they can find, including blocking exports of critical vaccine
components, which will lead to the breakdown of supply chains for raw ingredients,
syringes, and vials. Desperate governments may also strike short-term deals for
vaccines with adverse consequences for their long-term economic, diplomatic, and
strategic interests. The result will be not only needless economic and humanitarian
hardship but also intense resentment against vaccine-hoarding countries, which
will imperil the kind of international cooperation that will be necessary to tackle
future outbreaks—not to mention other pressing challenges, such as climate change
and nuclear proliferation.

Stay informed.

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It is not too late for global cooperation to prevail over global dysfunction, but it will
require states and their political leaders to change course. What the world needs is
an enforceable COVID-19 vaccine trade and investment agreement that would
alleviate the fears of leaders in vaccine-producing countries, who worry that sharing
their output would make it harder to look after their own populations. Such an
agreement could be forged and fostered by existing institutions and systems. And it
would not require any novel enforcement mechanisms: the dynamics of vaccine
manufacturing and global trade generally create layers of interdependence, which
would encourage participants to live up to their commitments. What it would
require, however, is leadership on the part of a majority of vaccine-manufacturing
countries—including, ideally, the United States.

WINNERS AND LOSERS

The goal of a vaccine is to raise an immune response so that when a vaccinated
person is exposed to the virus, the immune system takes control of the pathogen
and the person does not get infected or sick. The vaccine candidates against
COVID-19 must be proved to be safe and effective first in animal studies, then in
small trials in healthy volunteers, and finally in large trials in representative groups
of people, including the elderly, the sick, and the young.

Most of the candidates currently in the pipeline will fail. If one or more vaccines are
proved to be safe and effective at preventing infection and a large enough share of a
population gets vaccinated, the number of susceptible individuals will fall to the
point where the coronavirus will not be able to spread. That population-wide
protection, or “herd immunity,” would benefit everyone, whether vaccinated or not.

It is not clear yet whether achieving herd immunity will be possible with this
coronavirus. A COVID-19 vaccine may prove to be more like the vaccines that
protect against influenza: a critical public health tool that reduces the risk of
contracting the disease, experiencing its most severe symptoms, and dying from it,
but that does not completely prevent the spread of the virus. Nevertheless, given the
potential of vaccines to end or contain the most deadly pandemic in a century,
world leaders as varied as French President Emmanuel Macron, Chinese President
Xi Jinping, and UN Secretary-General António Guterres have referred to them as
global public goods—a resource to be made available to all, with the use of a vaccine
in one country not interfering with its use in another.

At least initially, however, that will not be the reality. During the period when global
supplies of COVID-19 vaccines remain limited, providing them to some people will
necessarily delay access for others. That bottleneck will prevent any vaccine from
becoming a truly global public good.

It is not too late for global cooperation to prevail over global
dysfunction.

Vaccine manufacturing is an expensive, complex process, in which even subtle
changes may alter the purity, safety, or efficacy of the final product. That is why
regulators license not just the finished vaccine but each stage of production and
each facility where it occurs. Making a vaccine involves purifying raw ingredients;
formulating and adding stabilizers, preservatives, and adjuvants (substances that

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increase the immune response); and packaging doses into vials or syringes. A few
dozen companies all over the world can carry out that last step, known as “fill and
finish.” And far fewer can handle the quality-controlled manufacture of active
ingredients—especially for more novel, sophisticated vaccines, whose production
has been dominated historically by just four large multinational firms based in the
United States, the United Kingdom, and the European Union. Roughly a dozen
other companies now have some ability to manufacture such vaccines at scale,
including a few large outfits, such as the Serum Institute of India, the world’s
largest producer of vaccines. But most are small manufacturers that would be
unable to produce billions of doses.

Further complicating the picture is that some of today’s leading COVID-19 vaccine
candidates are based on emerging technologies that have never before been
licensed. Scaling up production and ensuring timely approvals for these novel
vaccines will be challenging, even for rich countries with experienced regulators. All
of this suggests that the manufacture of COVID-19 vaccines will be limited to a
handful of countries.

And even after vaccines are ready, a number of factors might delay their availability
to nonmanufacturing states. Authorities in producing countries might insist on
vaccinating large numbers of people in their own populations before sharing a
vaccine with other countries. There might also turn out to be technical limits on the
volume of doses and related vaccine materials that companies can produce each
day. And poor countries might not have adequate systems to deliver and administer
whatever vaccines they do manage to get.

During that inevitable period of delay, there will be many losers, especially poorer
countries. But some rich countries will suffer, too, including those that sought to
develop and manufacture their own vaccines but bet exclusively on the wrong
candidates. By rejecting cooperation with others, those countries will have gambled
their national health on hyped views of their own exceptionalism.

And even “winning” countries will needlessly suffer in the absence of an enforceable
scheme to share proven vaccines. If health systems collapse under the strain of the
pandemic and foreign consumers are ill or dying, there will be less global demand
for export-dependent industries in rich countries, such as aircraft or automobiles. If
foreign workers are under lockdown and cannot do their jobs, cross-border supply
chains will be disrupted, and even countries with vaccine supplies will be deprived
of the imported parts and services they need to keep their economies moving.

PAGING DR. HOBBES

Forecasts project that the coronavirus pandemic could kill 40 million people and
reduce global economic output by $12.5 trillion by the end of 2021. Ending this
pandemic as soon as possible is in everyone’s interest. Yet in most capitals, appeals
for a global approach have gone unheeded.

In fact, the early months of the pandemic involved a decided shift in the wrong
direction. In the face of global shortages, first China; then France, Germany, and
the European Union; and finally the United States hoarded supplies of respirators,
surgical masks, and gloves for their own hospital workers’ use. Overall, more than
70 countries plus the European Union imposed export controls on local supplies of
personal protective equipment, ventilators, or medicines during the first four

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months of the pandemic. That group includes most of the countries where potential
COVID-19 vaccines are being manufactured.

Such hoarding is not new. A vaccine was developed in just seven months for the
2009 pandemic of the influenza A virus H1N1, also known as swine flu, which killed
as many as 284,000 people globally. But wealthy countries bought up virtually all
the supplies of the vaccine. After the World Health Organization appealed for
donations, Australia, Canada, the United States, and six other countries agreed to
share ten percent of their vaccines with poorer countries, but only after determining
that their remaining supplies would be sufficient to meet domestic needs.

Vaccine allocation resembles the classic game theory problem known as
“the prisoner’s dilemma.”

Nongovernmental and nonprofit organizations have adopted two limited strategies
to reduce the risk of such vaccine nationalism in the case of COVID-19. First, CEPI
(the Coalition for Epidemic Preparedness Innovations), the Bill & Melinda Gates
Foundation, the nongovernmental vaccine partnership known as Gavi, and other
donors have developed plans to shorten the queue for vaccines by investing early in
the manufacturing and distribution capacity for promising candidates, even before
their safety and efficacy have been established. The hope is that doing so will reduce
delays in ramping up supplies in poor countries. This approach is sensible but
competes with better-resourced national initiatives to pool scientific expertise and
augment manufacturing capacity. What is more, shortening the queue in this
manner may exclude middle-income countries such as Pakistan, South Africa, and
most Latin American states, which do not meet the criteria for receiving donor
assistance. It would also fail to address the fact that the governments of
manufacturing countries might seize more vaccine stocks than they need,
regardless of the suffering elsewhere.

An alternative approach is to try to eliminate the queue altogether. More than a
dozen countries and philanthropies in initial pledges of $8 billion to the Access to
COVID-19 Tools (ACT) Accelerator, an initiative dedicated to the rapid
development and equitable deployment of vaccines, therapeutics, and diagnostics
for COVID-19. The ACT Accelerator, however, has so far failed to attract major
vaccine-manufacturing states, including the United States and India. In the United
States, the Trump administration has instead devoted nearly $10 billion to
Operation Warp Speed, a program designed to deliver hundreds of millions of
COVID-19 vaccines by January 2021—but only to Americans. Meanwhile, Adar
Poonawalla, the chief executive of the Serum Institute of India, has stated that “at
least initially,” any vaccine the company produces will go to India’s 1.3 billion
people. Other vaccine developers have made similar statements, pledging that host
governments or advanced purchasers will get the early doses if supplies are limited.

Given the lack of confidence that any cooperative effort would be able to overcome
such obstacles, more and more countries have tried to secure their own supplies.
France, Germany, Italy, and the Netherlands formed the Inclusive Vaccine Alliance
to jointly negotiate with vaccine developers and producers. That alliance is now part
of a larger European Commission effort to negotiate with manufacturers on behalf
of EU member states to arrange for advance contracts and to reserve doses of
promising candidates. In May, Xi told attendees at the World Health Assembly, the
decision-making body of the World Health Organization, that if Beijing succeeds in
developing a vaccine, it will share the results with the world, but he did not say

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when. In June, Anthony Fauci, the director of the U.S. National Institute of Allergy
and Infectious Diseases, expressed skepticism about that claim and told The Wall
Street Journal that he expects that the Chinese government will use its vaccines
“predominantly for the very large populace of China.” This summer, the United
States bought up virtually all the supplies of remdesivir, one of the first drugs
proven to work against COVID-19, leaving none for the United Kingdom, the EU,
or most of the rest of the world for three months.

LEARNING THE HARD WAY

Global cooperation on vaccine allocation would be the most efficient way to disrupt
the spread of the virus. It would also spur economies, avoid supply chain
disruptions, and prevent unnecessary geopolitical conflict. Yet if all other vaccine-
manufacturing countries are being nationalists, no one will have an incentive to
buck the trend. In this respect, vaccine allocation resembles the classic game theory
problem known as “the prisoner’s dilemma”—and countries are very much acting
like the proverbial prisoner.

“If we have learned anything from the coronavirus and swine flu H1N1 epidemic of
2009,” said Peter Navarro, the globalization skeptic whom President Donald Trump
appointed in March to lead the U.S. supply chain response to COVID-19, “it is that
we cannot necessarily depend on other countries, even close allies, to supply us with
needed items, from face masks to vaccines.” Navarro has done his best to make sure
everyone else learns this lesson, as well: shortly after he made that statement, the
White House slapped export restrictions on U.S.-manufactured surgical masks,
respirators, and gloves, including to many poor countries.

By failing to develop a plan to coordinate the mass manufacture and distribution of
vaccines, many governments—including the U.S. government—are writing off the
potential for global cooperation. Such cooperation remains possible, but it would
require a large number of countries to make an enforceable commitment to sharing
in order to overcome leaders’ fears of domestic opposition.

The time horizon for most political leaders is short, especially for those facing an
imminent election. Many remain unconvinced that voters would understand that
the long-term health and economic consequences of the coronavirus spreading
unabated abroad are greater than the immediate threat posed by their or their loved
ones’ having to wait to be vaccinated at home. And to politicians, the potential for
opposition at home may seem like a bigger risk than outrage abroad over their
hoarding supplies, especially if it is for a limited time and other countries are seen
as likely to do the same.

French President Emmanuel Macron tours a vaccine laboratory
in June 2020

Laurent Cipriani / Reuters

Fortunately, there are ways to weaken this disincentive to cooperate. First,
politicians might be more willing to forgo immunizing their entire populations in
order to share vaccines with other countries if there were reliable research
indicating the number and allocation of doses needed to achieve critical public
health objectives at home—such as protecting health-care workers, military

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personnel, and nursing home staffs; reducing the spread to the elderly and other
vulnerable populations; and breaking transmission chains. Having that information
would allow elected leaders to pledge to share vaccine supplies with other countries
only if they have enough at home to reach those goals. This type of research has
long been part of national planning for immunization campaigns. It has revealed,
for example, that because influenza vaccines induce a relatively weak immune
response in the elderly, older people are much better protected if the vaccination of
children, who are the chief spreaders, is prioritized. Such research does not yet exist
for COVID-19 but should be part of the expedited clinical trials that companies are
currently conducting for vaccine candidates.

A framework agreement on vaccine sharing would also be more likely to succeed if
it were undertaken through an established international forum and linked to
preventing the export bans and seizures that have disrupted COVID-19-related
medical supply chains. Baby steps toward such an agreement have already been
taken by a working group of G-20 trade ministers, but that effort needs to be
expanded to include public health officials. The result should be a COVID-19
vaccine trade and investment agreement, which should include an investment fund
to purchase vaccines in advance and allocate them, once they have been proved to
be safe and effective, on the basis of public health need rather than the size of any
individual country’s purse. Governments would pay into the investment fund on a
subscription basis, with escalating, nonrefundable payments tied to the number of
vaccine doses they secured and other milestones of progress. Participation of the
poorest countries should be heavily subsidized or free. Such an agreement could
leverage the international organizations that already exist for the purchase and
distribution of vaccines and medications for HIV/AIDS, tuberculosis, and malaria.
The agreement should include an enforceable commitment on the part of
participating countries to not place export restrictions on supplies of vaccines and
related materials destined for other participating countries.

The agreement could stipulate that if a minimum number of vaccine-producing
countries did not participate, it would not enter into force, reducing the risk to early
signatories. Some manufacturers would be hesitant to submit to a global allocation
plan unless the participating governments committed to indemnification, allowed
the use of product liability insurance, or agreed to a capped injury-compensation
program to mitigate the manufacturers’ risk. Linking the agreement to existing
networks of regulators, such as the International Coalition of Medicines Regulatory
Authorities, might help ease such concerns and would also help create a more
transparent pathway to the licensing of vaccines, instill global confidence, reduce
development costs, and expedite access in less remunerative markets.

WHAT YOU DON’T KNOW CAN HURT (AND HELP) YOU

Even if policymakers can be convinced about the benefits of sharing, cooperation
will remain a nonstarter if there is nothing to prevent countries from reneging on
an agreement and seizing local supplies of a vaccine once it has been proved to be
safe and effective. Cooperation will ensue only when countries are convinced that it
can be enforced.

The key thing to understand is that allocating COVID-19 vaccines will not be a one-
off experience: multiple safe and effective vaccines may eventually emerge, each
with different strengths and benefits. If one country were to deny others access to
an early vaccine, those other countries could be expected to reciprocate by

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withholding potentially more effective vaccines they might develop later. And game
theory makes clear that, even for the most selfish players, incentives for cooperation
improve when the game is repeated and players can credibly threaten quick and
effective punishment for cheating.

Which vaccine turns out to be most effective may vary by the target patient
population and setting. Some may be more suitable for children or for places with
limited refrigeration. Yet because the various vaccine candidates still in
development require different ingredients and different types of manufacturing
facilities, no one country, not even the United States, will be able to build all the
facilities that may later prove useful.

Today’s vaccine supply chains are unavoidably global.

Today’s vaccine supply chains are also unavoidably global. The country lucky
enough to manufacture the first proven vaccine is unlikely to have all the inputs
necessary to scale up and sustain production. For example, a number of vaccine
candidates use the same adjuvant, a substance produced from a natural compound
extracted from the Chilean soapbark tree. This compound comes mostly from Chile
and is processed in Sweden. Although Chile and Sweden do not manufacture
vaccines, they would be able to rely on their control of the limited supply of this
input to ensure access to the eventual output. Vaccine supply chains abound with
such situations. Because the science has not settled on which vaccine will work best,
it is impossible to fully anticipate and thus prepare for all the needed inputs.

The Trump administration, as well as some in Congress, has blamed the United
States’ failure to produce vast supplies of everything it needs to respond to
COVID-19 on “dependency.” But when it comes to creating an enforceable
international vaccine agreement, complex cross-border supply chains are a feature,
not a bug. Even countries without vaccine-manufacturing capacity can credibly
threaten to hold up input supplies to the United States or other vaccine-
manufacturing countries if they engage in vaccine nationalism.

The Trump administration was reminded of this dynamic in April, when the
president invoked the Defense Production Act and threatened to ban exports to
Canada and Mexico of respirators made by 3M. Had Trump followed through,
Canada could have retaliated by halting exports of hospital-grade pulp that U.S.
companies needed to produce surgical masks and gowns. Or Canada could have
stopped Canadian nurses and hospital workers from crossing the border into
Michigan, where they were desperately needed to treat American patients. Mexico,
for its part, could have cut off the supply of motors and other components that U.S.
companies needed to make ventilators. The White House seemed unaware of these
potential vulnerabilities. Once it got up to speed, the administration backed off.

Of course, the Trump administration should have already learned that trading
partners—even historical allies—are willing and able to swiftly and effectively
retaliate against one another if someone breaks an agreement. In early 2018, this
was apparently an unknown—at least to Navarro. Explaining why Trump was
planning to put tariffs on steel and aluminum, Navarro reassured Americans: “I
don’t believe there is any country in the world that is going to retaliate,” he
declared. After Trump imposed the duties, Canada, Mexico, and the European
Union, along with China, Russia, and Turkey, all immediately retaliated. The EU
went through a similar learning experience in March. The European Commission
originally imposed a broad set of export restrictions on personal protective

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equipment. It was forced to quickly scale them back after realizing that cutting off
non-EU members, such as Norway and Switzerland, could imperil the flow of parts
that companies based in the EU needed to supply the EU’s own member states with
medical supplies.

American and European policymakers now understand—or at least should
understand—that what they don’t know about cross-border flows can hurt them.
Paradoxically, this lack of information may help convince skeptical policymakers to
maintain the interdependence needed to fight the pandemic. Not knowing what
they don’t know reduces the risk that governments will renege on a deal tomorrow
that is in their own best interest to sign on to today.

THE POWER OF FOMO

When the oxygen masks drop in a depressurizing plane, they drop at the same time
in every part of the plane because time is of the essence and because that is the best
way to ensure the safety of all onboard. The same is true of the global, equitable
allocation of safe and effective vaccines against COVID-19.

Vaccine nationalism is not just morally and ethically reprehensible: it is contrary to
every country’s economic, strategic, and health interests. If rich, powerful countries
choose that path, there will be no winners—ultimately, every country will be a loser.
The world is not doomed to learn this the hard way, however. All the necessary
tools exist to forge an agreement that would encourage cooperation and limit the
appeal of shortsighted “my country first” approaches.

But time is running out: the closer the world gets to the day when the first proven
vaccines emerge, the less time there is to set up an equitable, enforceable system for
allocating them. As a first step, a coalition of political leaders from countries
representing at least 50 percent of global vaccine-manufacturing capacity must get
together and instruct their public health officials and trade ministers to get out of
their silos and work together. Combining forces, they should hammer out a short-
term agreement that articulates the conditions for sharing, including with the
legions of poorer, nonmanufacturing countries, and makes clear what would
happen to participants who subsequently reneged and undertook vaccine
nationalism. Such a step would get the ball rolling and convince even more of the
manufacturing countries to sign on. The fear of missing out on vaccine access, in
the event their countries’ own vaccine candidates fail, may be what it takes to
pressure even today’s most reluctant leaders to cooperate.

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